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Medical, health, and genomics

Digital pathology helps decode tumor microenvironments for precision immunotherapy. GigaPath is a novel vision transformer that can scale to gigapixel whole-slide images by adapting dilated attention for digital pathology. In joint work with Providence and UW, we’re sharing Prov-GigaPath, the first whole-slide pathology foundation model pretrained on large-scale real-world data, for advancing clinical research and discovery.

GigaPath: Whole-Slide Foundation Model for Digital Pathology

Research Forum Ep2 | Panel | Transforming the Natural Sciences with AI

Research Forum 2 | Panel Discussion: Transforming the Natural Sciences with AI

white icons of first aid kit, DNA strand, laptop monitor with overlapping eye, and microscope on a blue and green gradient background

Scaling early detection of esophageal cancer with AI

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Microsoft Health Futures

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Publication

Deep learning guided design of protease substrates

Carmen Martin-Alonso, Sarah Alamdari, Tahoura S. Samad, Kevin Kaichuang Yang, Sangeeta N. Bhatia, Ava P. Amini

bioRxiv | March 2025

Publication

Scalable Universal T-Cell Receptor Embeddings from Adaptive Immune Repertoires

Paidamoyo Chapfuwa, Ilker Demirel, Lorenzo Pisani, Javier Zazo, Elon Portugaly, H. Jabran Zahid, Julia Greissl

ICLR 2025 | March 2025

Github

Publication

Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm

Meghana Kshirsagar, Artur Meller, Ian R. Humphreys, Samuel Sledzieski, Yixi Xu, Rahul Dodhia, Eric Horvitz, Bonnie Berger, Gregory R. Bowman, Juan M. Lavista Ferres, David Baker, Minkyung Baek

Nature Communications | February 2025

Project

Video

AI for Precision Health: Learning the language of nature and patients

February 25, 2025 | Hoifung Poon, Ava Amini, Lili Qiu, Matthew Lungren, Carlo Bifulco

Hosted by Hoifung Poon, with Lili Qiu, Ava Amini, Carlo Bifulco, and Matthew Lungren at Microsoft Research Forum, Episode 5 This panel discussion with Microsoft researchers and external guests explores the transformative potential of generative AI in learning the language of…

44:59

Video

Keynote: Multimodal Generative AI for Precision Health

February 25, 2025 | Hoifung Poon

Presented by Hoifung Poon at Microsoft Research Forum, Episode 5 Hoifung Poon, General Manager of Microsoft Health Futures, introduces an agenda in precision health, utilizing generative AI to pretrain high-fidelity patient embeddings from multimodal, longitudinal patient journeys. This…

17:14

Event

Microsoft Research Forum

February 25, 2025 | Virtual

Microsoft Research Forum Location: Virtual Register for the series Join us for a continuous exchange of ideas about science and technology research in the era of general AI. This series explores recent research advances, bold new…

Research Forum | abstract background with colorful hexagons

Publication

Consequences of training data composition for deep learning models in single-cell biology

Ajay Nadig, Akshaya Thoutam, Madeline Hughes, Anay Gupta, Andrew W. Navia, Nicolo Fusi, Srivatsan Raghavan, Peter S. Winter, Ava P. Amini, Lorin Crawford

bioRxiv | February 2025

Project

Microsoft Research Blog

Exploring the structural changes driving protein function with BioEmu-1

February 20, 2025 | Sarah Lewis, Tim Hempel, Jose Jimenez-Luna, Michael Gastegger, Yu Xie, Victor García Satorras, Osama Abdin, Bas Veeling, Ryota Tomioka, Frank Noé

Meet BioEmu-1 from Microsoft Research. This deep learning model can generate thousands of protein structures per hour, unlocking new possibilities for protein scientists and drug discovery and research.

The image shows eight different 3D models of protein structures. Each model is color-coded with various segments in blue, green, orange, and other colors to highlight different parts of the protein.

Publication

Addressing biomedical data challenges and opportunities to inform a large-scale data lifecycle for enhanced data sharing, interoperability, analysis, and collaboration across stakeholders

Vivek Sriram, Ashley Conard, Ilyana Rosenberg, Dokyoon Kim, Scott Saponas, Amanda K. Hall

Scientific Reports | February 2025, Vol 15

Publication

Leveraging public data: Changes in local economic distress and drug overdose deaths at the county level, 2000 – 2019

Shaddy K. Saba, Juan M. Lavista Ferres, Bill Weeks

International Journal of Public Health | February 2025

Project

Medical, health, and genomics

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