Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa
- Angelique Hölzemer ,
- Christina F Thobakgale ,
- Camilo A Jimenez Cruz ,
- Wilfredo F Garcia-Beltran ,
- Jonathan M. Carlson ,
- Nienke H van Teijlingen ,
- Jaclyn K Mann ,
- Manjeetha Jaggernath ,
- Seung-gu Kang ,
- Christian Körner ,
- Amy W Chung ,
- Jamie L Schafer ,
- David T Evans ,
- Galit Alter ,
- Bruce D Walker ,
- Philip J Goulder ,
- Mary Carrington ,
- Pia Hartmann ,
- Thomas Pertel ,
- Ruhong Zhou ,
- Thumbi Ndung’u ,
- Marcus Altfeld
Plos Medicine |
Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure.