A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape
- Henrik N Kløverpris ,
- David K Cole ,
- Anna Fuller ,
- Jonathan M. Carlson ,
- Konrad Beck ,
- Andrea J Schauenburg ,
- Pierre J Rizkallah ,
- Søren Buus ,
- Andrew K Sewel ,
- Philip Goulder
Retrovirology |
Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown.